Acetylenic inhibitors of sheep vesicular gland oxygenase
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چکیده
منابع مشابه
Acetylenic inhibitors of sheep vesicular gland oxygenase.
Biosynthesis of prostaglandins could be stopped by several acetylenic acids. They interfered with the oxygenase activity of the sheep vesicular gland enzymic system in two distinct patterns: an instantaneous, concentration-dependent effect and a time-dependent, destructive effect. Constants for both effects are reported. No measurable oxygen consumption tias observed with the acetylenic analogs...
متن کاملThe inhibition of the fatty acid oxygenase of sheep vesicular gland by antioxidants.
Antioxidants inhibit the fatty acid oxygenase of sheep vesicular gland and soybean lipoxygenase in an ins~~n~us, reversible manner. Their in~bito~ effectiveness was not related to their traditional antioxidant potencies but seemed to depend on the nature of the enzyme. The destructive effect of eicosa-58, I I, +tetraynoic acid, a substrate analog, on vesicular gland oxygenase could be prevented...
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Unsaturated fatty acids present in the lipids of essential fatty acid (EFA)deficient rats were found to inhibit the oxygenase activity of sheep vesicular gland in an instantaneous, reversible manner. However, competitive inhibition by high levels of these acids cannot account fully for the reported loss of prostaglandin synthetic capacity of these EFA-deficient animals. A similar competitive in...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
سال: 1973
ISSN: 0005-2760
DOI: 10.1016/0005-2760(73)90095-7